Stereoelectronic effects on polyproline conformation

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Stereoelectronic effects on polyproline conformation.

The polyproline type II (PPII) helix is a prevalent conformation in both folded and unfolded proteins, and is known to play important roles in a wide variety of biological processes. Polyproline itself can also form a type I (PPI) helix, which has a disparate conformation. Here, we use derivatives of polyproline, (Pro)10, (Hyp)10, (Flp)10, and (flp)10, where Hyp is (2S,4R)-4-hydroxyproline, Flp...

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ژورنال

عنوان ژورنال: Protein Science

سال: 2006

ISSN: 0961-8368,1469-896X

DOI: 10.1110/ps.051779806